abstract：OBJECTIVES:To determine the impact of disease progression on health-related quality of life in amyotrophic lateral sclerosis (ALS). METHODS:A total of 161 patients with ALS were enrolled. Assessments included the revised ALS Functional Rating Scale and the ALS Assessment Questionnaire (ALSAQ-40). Data analysis compris...

journal_title：Journal of the neurological sciences

authors： Prell T,Gaur N,Stubendorff B,Rödiger A,Witte OW,Grosskreutz J

更新日期：2019-02-15 00:00:00

abstract：INTRODUCTION:TCS is a well-established technique for diagnosis of Parkinson's disease (PD). Volumetric 3D-TCS is a promising complementary approach for objective acquisition and analysis, in particular for less experienced sonographers. This study provides baselines for Parkinson detection (sensitivity and specificity)...

journal_title：Journal of the neurological sciences

authors： Plate A,Maiostre J,Levin J,Bötzel K,Ahmadi SA

更新日期：2019-02-15 00:00:00

abstract：:Lower limb neuropathic pain in HIV patients is a common manifestation of sensory neuropathy (HIV-SN), but can be seen in patients who do not meet standard definitions of HIV-SN. The drug stavudine is a risk factor for HIV-SN, but some patients treated without stavudine experience HIV-SN, and the prevalence and risk fa...

journal_title：Journal of the neurological sciences

authors： Octaviana F,Safri AY,Setiawan DD,Estiasari R,Imran D,Ranakusuma T,Price P

更新日期：2019-02-15 00:00:00

abstract：OBJECTIVE:Despite the wide utilization of mechanical thrombectomy (MT) for acute ischemic stroke treatment, little is known about the incidence of early post-thrombectomy seizures, its predictors, and association with long-term outcome. METHODS:Using a prospective registry of mechanical thrombectomy in ischemic stroke...

journal_title：Journal of the neurological sciences

authors： Anadani M,Lekoubou A,Almallouhi E,Alawieh A,Chatterjee A,Vargas J,Spiotta AM

更新日期：2019-01-15 00:00:00

abstract：PURPOSE:To describe additional cases of subacute encephalopathy with seizures in alcoholics (SESA) syndrome, and to question the clinical and radiological course. METHODS:We retrospectively analyzed the clinical characteristics, electroencephalography (EEG), MRI studies at the admission and over the following 6 months...

journal_title：Journal of the neurological sciences

authors： Duwicquet C,Biberon J,Corcia P,De Toffol B,Limousin N

更新日期：2019-01-15 00:00:00

abstract：:We review post-infectious and post-vaccination neurological syndromes involving peripheral and central nervous system (CNS) and report an illustrative case of simultaneous occurrence of Guillain-Barré syndrome (GBS), confirmed by nerve conduction velocities, plus MRI-demonstrated transverse myelitis (TM) and acute enc...

journal_title：Journal of the neurological sciences

authors： Mancera-Páez O,Román GC,Pardo-Turriago R,Rodríguez Y,Anaya JM

更新日期：2018-12-15 00:00:00

abstract：:Parkinson's disease (PD) is the second most frequent neurodegenerative disorder. Impaired metabolism of alpha-synuclein (SNCA) and its aggregation are implicated in PD pathogenesis. SNCA has been identified as a highly significant genetic risk loci associated with the sporadic form of PD in across populations in GWAS ...

journal_title：Journal of the neurological sciences

authors： Emelyanov A,Kulabukhova D,Garaeva L,Senkevich K,Verbitskaya E,Nikolaev M,Andoskin P,Kopytova A,Milyukhina I,Yakimovskii A,Timofeeva A,Prakhova L,Ilves A,Vlasova I,Pchelina S

更新日期：2018-12-15 00:00:00

abstract：OBJECTIVE:Report on the kind and distribution of somatotopic sensation loss and its utility in assessing severity of sensation loss in study of a large international cohort of patients with hereditary transthyretin amyloidosis with polyneuropathy (hATTR-PN). METHODS:Smart Somatotopic Quantitative Sensation Testing (S ...

journal_title：Journal of the neurological sciences

authors： Pinto MV,Dyck PJB,Gove LE,McCauley BM,Ackermann EJ,Hughes SG,Waddington-Cruz M,Dyck PJ

更新日期：2018-11-15 00:00:00

abstract：BACKGROUND:Previous studies regarding the association between restless legs syndrome (RLS) and Parkinson's disease (PD) have produced contradictory results. However, the time frame between them has varied across these studies, and also, the longitudinal trajectroy of RLS symptoms has not been considered. OBJECTIVE:To ...

journal_title：Journal of the neurological sciences

authors： Iwaki H,Hughes KC,Gao X,Schwarzschild MA,Ascherio A

更新日期：2018-11-15 00:00:00

abstract：OBJECT:We aimed to investigate the link between the autonomic nervous system (ANS) impairment, assessed using baroreflex sensitivity (BRS) and heart rate variability (HRV) indices, and mortality after aneurysmal subarachnoid haemorrhage (aSAH). METHODS:A total of 57 patients (56 ± 18 years) diagnosed with aSAH were re...

journal_title：Journal of the neurological sciences

authors： Uryga A,Burzyńska M,Tabakow P,Kasprowicz M,Budohoski KP,Kazimierska A,Smielewski P,Czosnyka M,Goździk W

更新日期：2018-11-15 00:00:00

abstract：INTRODUCTION:To evaluate the non-ataxic clinical manifestations in genetically proven Spinocerebellar ataxia 2 (SCA2) and identify their determinants and predictors. METHODS:Seventy-three subjects with genetically proven SCA2 were evaluated clinically for the common non-ataxic manifestations. Based on the presence or ...

journal_title：Journal of the neurological sciences

authors： Stezin A,Venkatesh SD,Thennarasu K,Purushottam M,Jain S,Yadav R,Pal PK

更新日期：2018-11-15 00:00:00

abstract：BACKGROUND:The study aim was to evaluate the safety and efficacy of endovascular treatment (EVT) versus medical treatment (MT) in patients with symptomatic vertebral artery (VA) stenosis. METHODS:Randomized controlled trials with active and control groups receiving EVT plus MT and MT alone in patients with vertebro-ba...

journal_title：Journal of the neurological sciences

authors： Lattanzi S,Brigo F,Di Napoli M,Cagnetti C,Corradetti T,Silvestrini M

更新日期：2018-08-15 00:00:00

abstract：:Perampanel (PER) is a selective non-competitive α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor antagonist, licensed as adjunctive therapy in focal epilepsy and primary generalized tonic-clonic seizures (pGTCSs). We performed a retrospective study on highly refractory adult patients taking PER, w...

journal_title：Journal of the neurological sciences

authors： Morano A,Fattouch J,Albini M,Casciato S,Fanella M,Basili LM,Viganò A,Manfredi M,Giallonardo AT,Di Bonaventura C

更新日期：2018-07-15 00:00:00

abstract：OBJECTIVES:To address practical issues in measuring autoantibodies to neuronal cell-surface antigens (NSAs) in various autoimmune neurological disorders (ANDs). METHODS:We retrospectively reviewed the clinical information of 221 patients with clinically suspected ANDs who underwent antibody testing for NSAs between Ja...

journal_title：Journal of the neurological sciences

authors： Kaneko J,Kanazawa N,Tominaga N,Kaneko A,Suga H,Usui R,Ishima D,Kitamura E,Akutsu T,Yoshida K,Nishiyama K,Iizuka T

更新日期：2018-07-15 00:00:00

abstract：OBJECTIVE:Neurodegenerative diseases are often characterized by the presence of intracellular or extracellular protein aggregates in the central nervous system. Mutations of TARDBP gene have been shown to cause Amyotrophic Lateral Sclerosis and have been reported to present with clinical heterogeneity including parkins...

journal_title：Journal of the neurological sciences

authors： Gagliardi M,Arabia G,Nisticò R,Iannello G,Procopio R,Manfredini L,Annesi G,Quattrone A

更新日期：2018-07-15 00:00:00

abstract：OBJECTIVE:To investigate whether there is a difference in the neuro-autonomic and hemodynamic parameters in patients with postural tachycardia syndrome (POTS) according to onset time of orthostatic tachycardia during the Head-up tilt (HUT) test. METHODS:We retrospectively reviewed neuro-autonomic and hemodynamic data ...

journal_title：Journal of the neurological sciences

authors： Lee H,Kim HA

更新日期：2018-07-15 00:00:00

abstract：:Since the original description of side effects of neuroleptics, different terminologies and definitions for tardive dyskinesia (TD) and tardive syndrome (TS) have been used by different authors, and often these two terms have been used interchangeably. This paper proposes a nosology designed to define and clarify vari...

journal_title：Journal of the neurological sciences

authors： Frei K,Truong DD,Fahn S,Jankovic J,Hauser RA

更新日期：2018-06-15 00:00:00

abstract：OBJECTIVES:To examine the relationship between homeostatic model of insulin resistance (HOMA-IR) and cognitive test performance among population≥60years in a national database. HYPOTHESIS:Higher insulin resistance is associated with lower cognitive test performance score in the population≥60years. PARTICIPANTS:We ana...

journal_title：Journal of the neurological sciences

authors： Sherzai AZ,Shaheen M,Yu JJ,Talbot K,Sherzai D

更新日期：2018-05-15 00:00:00

abstract：BACKGROUND:Tele-rehabilitation after stroke holds promise for under-resourced settings, especially sub-Saharan Africa (SSA), with its immense stroke burden and severely limited physical therapy services. OBJECTIVE:To preliminarily assess the feasibility and outcomes of mobile technology-assisted physical therapy exerc...

journal_title：Journal of the neurological sciences

authors： Sarfo FS,Adusei N,Ampofo M,Kpeme FK,Ovbiagele B

更新日期：2018-04-15 00:00:00

abstract：PURPOSE:We compared clinical characteristics and outcomes of the early-onset seizure post-stroke patients who had seizures occurring at stroke presentation (SSP) with other patients without SSP at a single institution in Eastern China. METHODS:We reviewed 20,947 ischemic stroke patients in our hospital electronic medi...

journal_title：Journal of the neurological sciences

authors： Cheng JH,Zhang Z,Ye Q,Ye ZS,Xia NG

更新日期：2018-04-15 00:00:00

abstract：BACKGROUND:The relationship between fatigue impact and walking capacity and perceived ability in patients with multiple sclerosis (MS) is inconclusive in the existing literature. A better understanding might guide new treatment avenues for fatigue and/or walking capacity in patients with MS. OBJECTIVE:To investigate t...

journal_title：Journal of the neurological sciences

authors： Dalgas U,Langeskov-Christensen M,Skjerbæk A,Jensen E,Baert I,Romberg A,Santoyo Medina C,Gebara B,Maertens de Noordhout B,Knuts K,Béthoux F,Rasova K,Severijns D,Bibby BM,Kalron A,Norman B,Van Geel F,Wens I,Feys P

更新日期：2018-04-15 00:00:00

abstract：:PHARC (Polyneuropathy, Hearing loss, Ataxia, Retinitis pigmentosa and Cataracts) (MIM# 612674) is an autosomal recessive neurodegenerative disease caused by mutations in the ABHD12 gene. We evaluated two Spanish siblings affected with pes cavus, sensorimotor neuropathy, hearing loss, retinitis pigmentosa and juvenile ...

journal_title：Journal of the neurological sciences

authors： Frasquet M,Lupo V,Chumillas MJ,Vázquez-Costa JF,Espinós C,Sevilla T

更新日期：2018-04-15 00:00:00

abstract：BACKGROUND:Both intra-arterial recombinant tissue plasminogen activator (rt-PA) and stent retrieval are effective for treating acute ischemic stroke. The goal of this study was to evaluate the effectiveness of stent retrieval combined with intra-arterial rt-PA administration via micro-catheter (called the complex techn...

journal_title：Journal of the neurological sciences

authors： Yi TY,Chen WH,Wu YM,Zhang MF,Lin DL,Lin XH

更新日期：2018-03-15 00:00:00

abstract：BACKGROUND:Several correlations between cognitive impairment (CI), radiologic markers and cognitive reserve (CR) have been documented in MS. OBIECTIVE:To evaluate correlation between CI and brain volume (BV) considering CR as possibile mitigating factor. METHODS:195 relapsing MS patients underwent a neuropsychologica...

journal_title：Journal of the neurological sciences

authors： Fenu G,Lorefice L,Arru M,Sechi V,Loi L,Contu F,Cabras F,Coghe G,Frau J,Fronza M,Sbrescia G,Lai V,Boi M,Mallus S,Murru S,Porcu A,Barracciu MA,Marrosu MG,Cocco E

更新日期：2018-03-15 00:00:00

abstract：:Regular health checkups for mothers of patients with Duchenne muscular dystrophy have been performed at National Hospital Organization Tokushima Hospital since 1994. Among 43 mothers participated in this study, 28 dystrophinopathy carriers were identified. Skeletal and cardiac muscle functions of these subjects were e...

journal_title：Journal of the neurological sciences

authors： Adachi K,Hashiguchi S,Saito M,Kashiwagi S,Miyazaki T,Kawai H,Yamada H,Iwase T,Akaike M,Takao S,Kobayashi M,Ishizaki M,Matsumura T,Mori-Yoshimura M,Kimura E

更新日期：2018-03-15 00:00:00

abstract：OBJECTIVE:The purpose of this study is to identify predictors of stroke-related readmissions at 30days on a safety net hospital level and suggest interventions to reduce the number of readmissions. BACKGROUND:Hospital readmissions are an important measure of the quality of health care services. Readmissions indicate u...

journal_title：Journal of the neurological sciences

authors： Parikh S,George P,Wilson K,Rybin D,Hohler AD

更新日期：2018-02-15 00:00:00

abstract：IMPORTANCE:Workers exposed to aerosolized brain in a swine-processing plant developed immune-mediated polyradiculoneuropathy (IP) possibly triggered by an immune response. OBJECTIVE:Immunohistochemistry results were correlated with electrophysiological variables to examine the immunopathogenesis of this disorder. DES...

journal_title：Journal of the neurological sciences

authors： Muley SA,Holzbauer S,Clark B,Sejvar J,Lynfield R,Parry G,DeVries AS

更新日期：2018-02-15 00:00:00

abstract：BACKGROUND:Orthostatic hypotension (OH) is a commonly reported sign of the cardiovascular autonomic dysfunctions associated with Parkinson's disease (PD). Patients might suffer from a variety of the clinical symptoms of OH, including dizziness, lightheadedness, or problems with vision and fatigue. OBJECTIVES:To determ...

journal_title：Journal of the neurological sciences

authors： Klanbut S,Phattanarudee S,Wongwiwatthananukit S,Suthisisang C,Bhidayasiri R

更新日期：2018-02-15 00:00:00

abstract：BACKGROUND:The spectrum of symptoms exhibited by patients with essential tremor (ET) extends far beyond the classical tremor. This study aims to explore and establish the presence of subtle balance abnormalities in ET using dynamic posturography (DP). METHODS:DP was performed on 18 patients with ET and 26 controls. Di...

journal_title：Journal of the neurological sciences

authors： Prasad S,Velayutham SG,Reddam VR,Stezin A,Jhunjhunwala K,Pal PK

更新日期：2018-02-15 00:00:00

abstract：PURPOSE:This study aimed to develop a conceptual understanding of the specific characteristics of palliative care in neurology and the challenges of providing palliative care in the setting of neurological illness. METHOD:The study was conducted at London Health Sciences Centre in Canada using grounded theory methodol...

journal_title：Journal of the neurological sciences

authors： Gofton TE,Chum M,Schulz V,Gofton BT,Sarpal A,Watling C

更新日期：2018-02-15 00:00:00

abstract：BACKGROUND:Clinical disagreement over antiplatelet (AP) resumption in patients with primary intracranial hemorrhage (ICH) has long existed. This meta-analysis aimed to evaluate the benefits of AP resumption on preventing ischemic or thromboembolic events against its risks of promoting ICH recurrence or hematoma expansi...

journal_title：Journal of the neurological sciences

authors： Ding X,Liu X,Tan C,Yin M,Wang T,Liu Y,Mo L,Wei X,Tan X,Deng F,Chen L

更新日期：2018-01-15 00:00:00

abstract：BACKGROUND:There is a need for biomarkers that can classify optic neuritis (ON) attacks as belonging to either neuromyelitis optica spectrum disorder with optic neuritis (NMOSD-ON) or relapsing remitting multiple sclerosis with optic neuritis (MS-ON). This study uses spectral domain optical coherence tomography (SD-OCT...

journal_title：Journal of the neurological sciences

authors： Bertsch-Gout M,Loeb R,Finch AK,Javed A,Bernard J

更新日期：2018-01-15 00:00:00

abstract：OBJECTIVE:To investigate the changes in the expression of repulsive guidance molecule b (RGMb) in brain tissue of rats with ischemic cerebral infarction and determine its relationship with axonal regeneration, synapse remodeling and magnetic resonance imaging (MRI) parameters with magnetic resonance diffusion tensor im...

journal_title：Journal of the neurological sciences

authors： Wang X,Cheng JL,Ran YC,Zhang Y,Yang L,Lin YN

更新日期：2017-12-15 00:00:00

abstract：:The relationship between blood pressure(BP) and clinical outcome in patients with acute stroke is still controversial. The present study aimed to elucidate the impact of admission blood pressure on mortality in patients with acute stroke of different subtypes. Data were from ChinaQUEST (QUality Evaluation of Stroke Ca...

journal_title：Journal of the neurological sciences

authors： Liu Y,Yang Y,Jin H,Fan C,Lv P,Sun W,Peng Q,Zhao M,Jin DK,Wang J,Wong LKS,Anderson CS,Zheng L,Huang Y,ChinaQUEST (Quality Evaluation of Stroke Care and Treatment) Investigators.

更新日期：2017-12-15 00:00:00

abstract：BACKGROUND:Molecular diagnosis of hereditary spastic paraplegias (HSP) is a difficult task due to great clinical and genetic heterogeneity. We aimed to characterize clinical and molecular findings of HSP families from Rio Grande do Sul, Brazil; and to evaluate the diagnostic yield of a next-generation sequencing (NGS) ...

journal_title：Journal of the neurological sciences

authors： Burguez D,Polese-Bonatto M,Scudeiro LAJ,Björkhem I,Schöls L,Jardim LB,Matte U,Saraiva-Pereira ML,Siebert M,Saute JAM

更新日期：2017-12-15 00:00:00

abstract：BACKGROUND:Ischemic stroke that is sufficiently severe to cause loss of consciousness has a high rate of morbidity and mortality. Many individuals who suffer from these disorders never recover conscious awareness. In this study, we aimed to identify an accurate and simple bedside method to predict awareness recovery af...

journal_title：Journal of the neurological sciences

authors： Hu Y,Wang C,Yan X,Fu H,Wang K

更新日期：2017-12-15 00:00:00

abstract：:Zika virus infection represents a new neuropathological agent with association to a wide spectrum of neurological complications: a) Congenital Zika Syndrome by affecting the neural stem cells of the human fetal brain; b) Guillain-Barré Syndrome by an autoimmune response against peripheral myelin and/or axonal componen...

journal_title：Journal of the neurological sciences

authors： Medina MT,Medina-Montoya M

更新日期：2017-12-15 00:00:00

abstract：BACKGROUND:Progressive supranuclear palsy is a neurodegenerative disorder characterized by high functional disability and rapidly progressive dependency. The predictors of survival are still unclear. METHODS:The predictors of survival were evaluated in a group of clinically diagnosed PSP patients, focusing primarily o...

journal_title：Journal of the neurological sciences

authors： Cosseddu M,Benussi A,Gazzina S,Manes MA,Dell'Era V,Cristillo V,Turrone R,Alberici A,Borroni B

更新日期：2017-11-15 00:00:00

abstract：INTRODUCTION:Cerebral hyperperfusion syndrome (CHS) and intracranial hemorrhage (ICH) after carotid revascularization have been associated with significant morbidity and mortality, although pooled data comparing these outcomes between open and endovascular treatment are lacking. Aim of this meta-analysis is to compare ...

journal_title：Journal of the neurological sciences

authors： Galyfos G,Sianou A,Filis K

更新日期：2017-10-15 00:00:00

abstract：BACKGROUND:Postganglionic cardiac sympathetic denervation is evident in patients with early-stage Parkinson's disease (PD). Cardiac iodine-123-meta-iodobenzylguanidine (MIBG) uptake is correlated with the non-motor symptoms of PD, suggesting that low cardiac MIBG uptake may reflect wider alpha-synuclein pathology. In a...

journal_title：Journal of the neurological sciences

authors： Choi MH,Yoon JH,Yong SW

更新日期：2017-10-15 00:00:00